Contribution of the adrenal cortex to renal and renoprival hypertension.
نویسندگان
چکیده
Association of the adrenal cortex with renal hypertension lead to the conclusioa that several mechanisms fare operating. First, hypertension is not, or is poorly sustained in true adrenal failure, and mild failure seems to impair vascular responsiveness. This indicates a permissive function of thme adrenal ill renal hypertension. Furthermore, degrees of renal injury or of hyper(orticoidism which are not of themselves very pressor may cause severe hypertension when they are added together. This additive aspect is probably closely related to the sellsitizing effect of adrenal steroids on renal pressor activity and underlies the so-called renimiDCA syndrome. It may involve not only an enhanced pressor responsiveness hut also a weakening of vessel walls. Lastly, the effects of renin and renal hypertension on the zona gloitnerulosa suggest that the renal pressor system has would tend to add cortical pressor to existing hypertension.
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ورودعنوان ژورنال:
- Circulation
دوره 17 4, Part 2 شماره
صفحات -
تاریخ انتشار 1958